Ozawa Nobuaki, Maruyama Tetsuo, Nagashima Takashi, Ono Masanori, Arase Toru, Ishimoto Hitoshi, Yoshimura Yasunori
Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo, Japan.
Fertil Steril. 2008 Oct;90(4):1301-4. doi: 10.1016/j.fertnstert.2007.09.051. Epub 2007 Dec 31.
Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments.
对2324对有反复流产史的日本夫妇进行的细胞遗传学调查显示，4.91%的夫妇（n = 114）存在染色体异常，包括相互易位（n = 74）、罗伯逊易位（n = 23）和倒位（n = 10）。亲代相互易位是随后流产的一个重要预测因素（调整后的优势比：3.6，95%置信区间：1.8 - 7.1），尽管进行了适当治疗，但携带染色体异常的夫妇发生的大多数流产是不可避免的，原因是核型异常。
