Department of Pediatrics, Translational Medicine Unit, King George's Medical University, Lucknow, India.
Indian J Med Res. 2017 Sep;146(3):316-327. doi: 10.4103/ijmr.IJMR_1624_14.
Preterm infants (i.e., born before <37 wk of gestation) are at increased risk of morbidity and mortality and long-term disabilities. Global prevalence of preterm birth (PTB) varies from 5 to 18 per cent. There are multiple aetiological causes and factors associated with PTB. Intrapartum infections are conventionally associated with PTB. However, maternal genotype modulates response to these infections. This review highlights the association of cytokine gene polymorphisms and their levels with PTB. Varying PTB rates across the different ethnic groups may be as a result of genetically mediated varying cytokines response to infections. Studies on genetic variations in tumour necrosis factor-alpha, interleukin-1 alpha (IL-1α), IL-1β, IL-6, IL-10 and toll-like receptor-4 genes and their association with PTB, have been reviewed. No single polymorphism of the studied genes was found to be associated with PTB. However, increased maternal levels of IL-1β and IL-6 and low levels of IL-10 have been found to be associated with PTB.
早产儿（即妊娠不足 37 周出生的婴儿）发病率和死亡率较高，且存在长期残疾风险。全球早产儿（PTB）的发病率从 5%到 18%不等。早产有多种病因和相关因素。分娩期感染通常与 PTB 相关。然而，母体基因型会调节对这些感染的反应。这篇综述强调了细胞因子基因多态性及其水平与 PTB 的关联。不同种族之间的 PTB 发生率不同，可能是由于遗传介导的对感染的细胞因子反应不同。对肿瘤坏死因子-α、白细胞介素-1α（IL-1α）、IL-1β、IL-6、IL-10 和 toll 样受体-4 基因的遗传变异及其与 PTB 的关系进行了研究。研究中没有发现单个基因多态性与 PTB 相关。然而，发现母体 IL-1β 和 IL-6 水平升高以及 IL-10 水平降低与 PTB 相关。
