Speer Paul D, Powers Robert W, Frank Michael P, Harger Gail, Markovic Nina, Roberts James M
Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Am J Obstet Gynecol. 2008 Jan;198(1):112.e1-7. doi: 10.1016/j.ajog.2007.05.052.
The purpose of this study was to investigate maternal plasma concentrations of asymmetric dimethylarginine (ADMA) in mid pregnancy and at the time of disease in women who experience preeclampsia, compared with women with uncomplicated pregnancies and women with small-for-gestational-age infants.
Plasma samples were collected at mid-pregnancy and at the time of delivery from 31 women with uncomplicated pregnancies, from 12 women with small-for-gestational-age infants, and from 15 women with preeclampsia. ADMA and L-arginine concentrations were measured using high-pressure liquid chromatography.
Maternal ADMA concentrations were elevated at mid pregnancy and remained elevated at delivery in women who later experienced preeclampsia (0.45 +/- 0.09 micromol/L) compared with women with uncomplicated pregnancies (0.34 +/- 0.08 micromol/L; P < .01) and with women with small-for-gestational-age infants (0.33 +/- 0.06 micromol/L; P < .01).
Maternal ADMA concentrations are higher in mid pregnancy in women who experience preeclampsia, compared with women with uncomplicated pregnancies and small-for-gestational-age infants. Elevated ADMA concentration before clinical onset of preeclampsia suggests a role of this nitric oxide synthase inhibitor in the pathophysiologic condition of preeclampsia.
本研究旨在调查子痫前期女性孕中期及发病时母体血浆中不对称二甲基精氨酸（ADMA）的浓度，并与正常妊娠女性及小于胎龄儿母亲进行比较。
收集了31例正常妊娠女性、12例小于胎龄儿母亲及15例子痫前期女性孕中期及分娩时的血浆样本。采用高压液相色谱法测定ADMA和L-精氨酸浓度。
与正常妊娠女性（0.34±0.08微摩尔/升；P<.01）及小于胎龄儿母亲（0.33±0.06微摩尔/升；P<.01）相比，子痫前期女性孕中期母体ADMA浓度升高，且分娩时仍维持在较高水平（0.45±0.09微摩尔/升）。
与正常妊娠女性及小于胎龄儿母亲相比，子痫前期女性孕中期母体ADMA浓度更高。子痫前期临床发病前ADMA浓度升高提示该一氧化氮合酶抑制剂在子痫前期病理生理过程中发挥作用。
