爱泼斯坦-巴尔病毒设定值的严格调控：HIV感染后爱泼斯坦-巴尔病毒DNA载量的个体差异保持不变。

Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection.

作者信息

Piriou Erwan, van Dort Karel, Otto Sigrid, van Oers Marinus H J, van Baarle Debbie

机构信息

Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Clin Infect Dis. 2008 Jan 15;46(2):313-6. doi: 10.1086/524079.

DOI:10.1086/524079

PMID:18171268

Abstract

Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.

摘要

随着时间的推移，健康个体外周血中携带恒定数量的感染爱泼斯坦-巴尔病毒的B细胞。在此，我们表明，HIV感染后，爱泼斯坦-巴尔病毒DNA水平的个体间差异得以维持，这为个体爱泼斯坦-巴尔病毒设定点的存在提供了证据。免疫激活可能导致人类免疫缺陷病毒血清转化后该设定点升高。