Aiello Allison E, Nguyen Hoang-Oanh T, Haan Mary N
Dept. of Epidemiology, Center for Social Epidemiology and Population Health, University of Michigan School of Public Health, 3659 SPH Tower, 109 Observatory, Ann Arbor, MI 48109-2029, USA.
J Infect Dis. 2008 Jan 1;197(1):34-41. doi: 10.1086/524144.
Although the apolipoprotein (APOE)-epsilon4 allele has been shown to determine the outcome of several infections, its relationship with cytomegalovirus (CMV) has not been explored. We examine whether APOE determines CMV and herpes simplex virus type 1 (HSV-1) antibody levels and assess whether C-reactive protein (CRP) mediates any observed relationships.
We conducted a cross-sectional analysis of a randomly selected subset (n = 1561/1789) of participants aged 60-101 in the Sacramento Area Latino Study on Aging. Blood samples were tested for APOE genotype, CRP, and immunoglobulin G antibodies to CMV and HSV-1. Multivariate logistic regression was used to examine the association between epsilon4 and CMV and HSV antibody levels. We also assessed whether CRP mediates the effects of any observed associations between epsilon4 and viral antibody levels.
CMV antibody and CRP levels varied significantly by APOE genotype. The association between CRP and CMV antibody was strengthened in the presence of epsilon4. In contrast, this effect was not observed in HSV-1. We found that APOE-epsilon4 carriers had significantly lower levels of CRP yet significantly higher levels of CMV antibodies, suggesting a mediating pathway.
APOE-epsilon4 carriers may experience immunological aberrations that lead to lower levels of CRP and correspondingly higher CMV antibody levels.
尽管载脂蛋白（APOE）-ε4等位基因已被证明可决定多种感染的结果，但其与巨细胞病毒（CMV）的关系尚未得到探讨。我们研究APOE是否决定CMV和1型单纯疱疹病毒（HSV-1）抗体水平，并评估C反应蛋白（CRP）是否介导任何观察到的关系。
我们对萨克拉门托地区拉丁裔老年人研究中随机抽取的60至101岁参与者子集（n = 1561/1789）进行了横断面分析。对血样进行APOE基因型、CRP以及CMV和HSV-1免疫球蛋白G抗体检测。采用多因素逻辑回归分析ε4与CMV和HSV抗体水平之间的关联。我们还评估了CRP是否介导ε4与病毒抗体水平之间任何观察到的关联的效应。
CMV抗体和CRP水平因APOE基因型而异。在存在ε4的情况下，CRP与CMV抗体之间的关联增强。相比之下，在HSV-1中未观察到这种效应。我们发现APOE-ε4携带者的CRP水平显著较低，但CMV抗体水平显著较高，提示存在一条介导途径。
APOE-ε4携带者可能经历免疫异常，导致CRP水平降低，相应地CMV抗体水平升高。
