Watanabe Yumi, Kitamura Kaori, Nakamura Kazutoshi, Sanpei Kazuhiro, Wakasugi Minako, Yokoseki Akio, Onodera Osamu, Ikeuchi Takeshi, Kuwano Ryozo, Momotsu Takeshi, Narita Ichiei, Endo Naoto
Division of Preventive Medicine, University of Niigata, Niigata, Japan.
JA Niigata Koseiren Sado General Hospital, University of Niigata, Niigata, Japan.
Dement Geriatr Cogn Dis Extra. 2016 Jan 19;6(1):10-9. doi: 10.1159/000442585. eCollection 2016 Jan-Apr.
BACKGROUND/AIMS: We aimed to determine whether the concentration of serum C-reactive protein (CRP) is associated with cognitive function in an adult Japanese population.
Participants of this cross-sectional study were from a subgroup of the Project in Sado for Total Health (PROST; n = 454; mean age, 70.5 years). The cognitive state was evaluated using the Mini-Mental State Examination (MMSE), and those with an MMSE score <24 were considered 'cognitively declined'. Concentrations of serum high-sensitivity CRP were measured. Multiple logistic regression analysis was used to calculate odds ratios (ORs) for cognitive decline, adjusting for the covariates of age, sex, BMI, disease history, and APOE allele.
Of the 454 participants, 94 (20.7%) were cognitively declined. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1.29 (95% CI 0.61-2.75) for the second, 1.78 (95% CI 0.82-3.86) for the third, and 3.05 (95% CI 1.45-6.42) for the highest (fourth) quartiles (p for trend = 0.018). When data were stratified by sex, the association between CRP concentration and cognitive decline was observed only in women.
Our findings suggest an association between higher CRP concentration and lower cognitive function. Chronic inflammation may affect cognitive function in adults, in particular women.
背景/目的：我们旨在确定日本成年人群中血清C反应蛋白（CRP）浓度是否与认知功能相关。
这项横断面研究的参与者来自佐渡全健康项目（PROST）的一个亚组（n = 454；平均年龄70.5岁）。使用简易精神状态检查表（MMSE）评估认知状态，MMSE评分<24分的参与者被认为“认知功能下降”。检测血清高敏CRP浓度。采用多因素logistic回归分析计算认知功能下降的比值比（OR），并对年龄、性别、体重指数、疾病史和载脂蛋白E等位基因等协变量进行校正。
454名参与者中，94名（20.7%）存在认知功能下降。相对于CRP浓度的最低（第一）四分位数，第二四分位数的校正OR为1.29（95%CI 0.61 - 2.75），第三四分位数为1.78（95%CI 0.82 - 3.86），最高（第四）四分位数为3.05（95%CI 1.45 - 6.42）（趋势p = 0.018）。按性别分层分析数据时，仅在女性中观察到CRP浓度与认知功能下降之间的关联。
我们的研究结果表明，较高的CRP浓度与较低的认知功能之间存在关联。慢性炎症可能影响成年人尤其是女性的认知功能。
