组织血型抗原与II型基因组诺如病毒临床感染易感性之间无关联。

No association between histo-blood group antigens and susceptibility to clinical infections with genogroup II norovirus.

作者信息

Halperin Tamar, Vennema Harry, Koopmans Marion, Kahila Bar-Gal Gila, Kayouf Raid, Sela Tamar, Ambar Ruhama, Klement Eyal

机构信息

Koret School of Veterinary Medicine, Faculty of Agricultural, Food, and Environmental Sciences, The Hebrew University, Rehovot, Israel.

出版信息

J Infect Dis. 2008 Jan 1;197(1):63-5. doi: 10.1086/524145.

DOI:10.1086/524145

PMID:18171286

Abstract

Noroviruses (NoVs) are a leading cause of viral gastroenteritis in humans. In the present study, the association between NoV susceptibility and the ABO histo-blood group was studied during 2 outbreaks of acute gastroenteritis in military units in Israel caused by genogroup II (GII) NoVs. The findings demonstrate that, unlike for genogroup I of NoV, there is no association between the ABO histo-blood group and clinical infection with GII NoVs. This is the largest study to test the association between NoVs, proven clinical infection with GII, and the ABO histo-blood group.

摘要

诺如病毒（NoVs）是人类病毒性肠胃炎的主要病因。在本研究中，在以色列军事单位由II型基因群（GII）诺如病毒引起的2次急性肠胃炎暴发期间，对诺如病毒易感性与ABO组织血型之间的关联进行了研究。研究结果表明，与I型基因群诺如病毒不同，ABO组织血型与GII型诺如病毒的临床感染之间没有关联。这是检验诺如病毒、已证实的GII临床感染与ABO组织血型之间关联的规模最大的研究。