University of Linkoping, 581 85 Linkoping, Sweden.
Emerg Infect Dis. 2010 Jan;16(1):81-7. doi: 10.3201/eid1601.090633.
Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes.
诺如病毒（NoV）被认为是成年人中最常见的急性肠胃炎病原体。疾病易感性与组织血型抗原和分泌状态有关；非分泌者几乎完全对疾病具有抵抗力。我们报告了一起食源性 GI.3 诺如病毒肠胃炎暴发事件，影响了 83 人中的 33 人（40%）。非分泌者和分泌者同样可能出现症状性疾病（比值比[OR]1.41，95%置信区间[CI]0.46-4.36 与 OR 0.71，95%CI0.23-2.18，p=0.57）。此外，不同 Lewis 或 ABO 表型的人之间的易感性也没有统计学差异。暴发菌株的衣壳基因与先前被证明可识别非分泌者唾液以及合成 Lewis a 的 Kashiwa645 GI.3 株具有高度的氨基酸同源性。此次诺如病毒暴发事件影响了无论分泌状态或 Lewis 或 ABO 表型如何的人群。
