Tamimi Rulla M, Brugge Joan S, Freedman Matthew L, Miron Alexander, Iglehart J Dirk, Colditz Graham A, Hankinson Susan E
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Cancer Res. 2008 Jan 1;68(1):18-21. doi: 10.1158/0008-5472.CAN-07-3234.
Colony stimulating factor-1 (CSF1) and its receptor (CSF1-R) are important in mammary gland development and have been implicated in breast carcinogenesis. In a nested case-control study in the Nurses' Heath Study of 726 breast cancer cases diagnosed between June 1, 1992, and June 1, 1998, and 734 matched controls, we prospectively evaluated whether circulating levels of CSF1 (assessed in 1989-1990) are associated with breast cancer risk. The association varied by menopausal status (P(heterogeneity) = 0.009). CSF1 levels in the highest quartile (versus lowest) were associated with an 85% reduced risk of premenopausal breast cancer [relative risk (RR), 0.15; 95% confidence interval (95% CI), 0.03-0.85; P(trend) = 0.02]. In contrast, CSF1 levels in the highest quartile conferred a 33% increased risk of postmenopausal breast cancer (RR, 1.33; 95% CI, 0.96-1.86; P(trend) = 0.11), with greatest risk for invasive (RR, 1.45; 95% CI, 1.02-2.07; P(trend) = 0.06) and ER+/PR+ tumors (RR, 1.72; 95% CI, 1.11-2.66; P(trend) = 0.04). Thus, the association of circulating CSF1 levels and breast cancer varies by menopausal status.
集落刺激因子-1（CSF1）及其受体（CSF1-R）在乳腺发育中起重要作用，并与乳腺癌发生有关。在护士健康研究的一项巢式病例对照研究中，对1992年6月1日至1998年6月1日期间诊断的726例乳腺癌病例和734例匹配对照进行研究，我们前瞻性评估了1989 - 1990年测定的循环CSF1水平是否与乳腺癌风险相关。这种关联因绝经状态而异（P（异质性）=0.009）。最高四分位数（与最低四分位数相比）的CSF1水平与绝经前乳腺癌风险降低85%相关[相对风险（RR），0.15；95%置信区间（95%CI），0.03 - 0.85；P（趋势）=0.02]。相反，最高四分位数的CSF1水平使绝经后乳腺癌风险增加33%（RR，1.33；95%CI，0.96 - 1.86；P（趋势）=0.11），侵袭性肿瘤（RR，1.45；95%CI，1.02 - 2.07；P（趋势）=0.06）和ER+/PR+肿瘤（RR，1.72；95%CI，1.11 - 2.66；P（趋势）=0.04）的风险最高。因此，循环CSF1水平与乳腺癌的关联因绝经状态而异。
