Renaudineau Y, Le Meur Y
Laboratory of Immunology, Brest University Medical School Hospital, Brest, France.
Clin Rev Allergy Immunol. 2008 Oct;35(1-2):22-9. doi: 10.1007/s12016-007-8066-6.
The term pauci-immune glomerulonephritis with vasculitis encompasses a group of auto-immune disorders, which includes Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and renal-limited vasculitis. Over the past few years, progress has been made in understanding the epidemiology and environmental and genetic risk factors of the role of antineutrophil cytoplasmic antibodies (ANCA) in kidney pathogenesis and the utilization of ANCA in diagnosis. However, certain aspects are still subject to debate including the classification and the place of ANCA in treatment.
伴有血管炎的少免疫性肾小球肾炎这一术语涵盖了一组自身免疫性疾病，其中包括韦格纳肉芽肿病、显微镜下多血管炎、变应性肉芽肿性血管炎和肾脏局限性血管炎。在过去几年中，在了解抗中性粒细胞胞浆抗体（ANCA）在肾脏发病机制中的作用的流行病学、环境和遗传危险因素以及ANCA在诊断中的应用方面取得了进展。然而，某些方面仍存在争议，包括分类以及ANCA在治疗中的地位。
