维生素C与超氧化物导致DNA链断裂的机制以及过氧化氢酶和超氧化物歧化酶的保护作用。
The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase.
作者信息
Morgan A R, Cone R L, Elgert T M
出版信息
Nucleic Acids Res. 1976 May;3(5):1139-49. doi: 10.1093/nar/3.5.1139.
Abstract
Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.
摘要
维生素C仅在有氧存在时才会使DNA断裂。超氧化物歧化酶对该反应无影响，但过氧化氢酶可抑制此反应。超氧化物也会导致DNA断裂，超氧化物歧化酶和过氧化氢酶均可抑制这种断裂。羟自由基似乎是造成链断裂的介质。
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