[IL-1, TNF and IL-6 production by alveolar mononuclear cells in patients with sarcoidosis].

Cytokines produced by locally activated T cells and macrophages have central role in lymphocyte alveolitis and granuloma formation, and it is beleived that they regulate activity and further progression of sarcoidosis. The aim of our study was to evaluate the levels of interleukin-1 (IL-1), tumor necrosis factor (TNF) and interleukin-6 (IL-6) production by bronchoalveolar mononuclear cells in 6 patients With sarcoidosis. The obtained results showed increased IL-6 levels in patients with active disease, IL-1 activity did not follow clinical changes, while TNF was detectible only in one patients.