甲真菌病生活质量量表：一种用于甲真菌病的生活质量评估工具。
NailQoL: a quality-of-life instrument for onychomycosis.
作者信息
Warshaw Erin M, Foster Jovonne K, Cham Peter M H, Grill Joseph P, Chen Suephy C
机构信息
Department of Dermatology, University of Minnesota, School of Medicine, Minneapolis, MN, USA.
出版信息
Int J Dermatol. 2007 Dec;46(12):1279-86. doi: 10.1111/j.1365-4632.2007.03362.x.
BACKGROUND
The disease burden onychomycosis is not trivial. The aim is to develop a quality of life instrument to measure the onychomycosis burden.
METHODS
402 patients with mycologically-confirmed onychomycosis completed a baseline questionnaire of 39 quality of life items (modified Skindex-29 questions and 10 additional nail-specific questions). Internal consistency, reproducibility and responsiveness of the final instrument, NailQoL were measured.
RESULTS
15 items consisting of symptom (3), emotion (10), and functional (2) domains were retained in NailQoL. Symptom and emotion subscales = 0.80-0.92. Administration alpha demonstrated good internal consistency (Cronbach's of the instrument to 46 patients at one month after baseline revealed good reproducibility (ICC 0.88-0.91). Responsiveness was measured in 292 patients at 18 months; statistically significant better NailQoL scores were found in individuals with complete cure (mycological and clinical) (P < 0.01).
CONCLUSION
NailQoL represents a new concise, valid, reliable, and responsive instrument for measuring burden of skin disease for patients with onychomycosis.
背景
甲癣的疾病负担不容小觑。目的是开发一种生活质量工具来衡量甲癣负担。
方法
402例经真菌学确诊的甲癣患者完成了一份包含39个生活质量项目的基线问卷（改良的Skindex - 29问题和10个额外的指甲特异性问题）。对最终工具NailQoL的内部一致性、可重复性和反应性进行了测量。
结果
NailQoL保留了由症状（3个）、情感（10个）和功能（2个）领域组成的15个项目。症状和情感子量表 = 0.80 - 0.92。对46例患者在基线后1个月进行工具的管理α显示出良好的内部一致性（Cronbach's）。对46例患者在基线后1个月进行测量显示出良好的可重复性（组内相关系数0.88 - 0.91）。在292例患者18个月时测量反应性；在完全治愈（真菌学和临床）的个体中发现NailQoL评分有统计学意义的更好改善（P < 0.01）。
结论
NailQoL是一种用于测量甲癣患者皮肤疾病负担的新的简洁、有效、可靠且有反应性的工具。
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