Nicholson Kimberly, Abramova Liana, Chren Mary-Margaret, Yeung Jensen, Chon Susan Y, Chen Suephy C
Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
J Am Acad Dermatol. 2007 Aug;57(2):213-21. doi: 10.1016/j.jaad.2007.01.048. Epub 2007 Apr 18.
No rosacea-specific quality-of-life (QOL) instrument exists.
We sought to develop a validated, reliable rosacea-specific instrument.
From 6 in-depth interviews, we composed 21 rosacea-specific items. These items and Skindex-29 were administered in a validation cohort (n = 59). Internal consistency reliability and reproducibility were measured with Cronbach's coefficient alpha and intraclass correlation coefficient, respectively. Responsiveness was assessed comparing baseline with 4- to 6-month responses. Construct validity was assessed with principal axes factor analyses. Discriminant validity was examined with an additional 38 patients comparing differences in responsiveness between the rosacea-specific QOL instrument and Skindex.
Reliability was high (Cronbach's alpha: 0.82-0.97, intraclass correlation coefficient: 0.70-0.95). The rosacea-specific QOL instrument showed preliminary responsiveness for patients with improved disease (P <or= .05). Principal axes factor analyses correlated to hypothesized scales (r = 0.57-0.82). Discriminant validity was illustrated with greater differences in responsiveness using the rosacea-specific QOL instrument (P = .008).
Potential selection bias and lack of generalizability was a limitation.
The rosacea-specific QOL instrument, RosaQoL, appears to be a reliable and valid QOL instrument and shows preliminary responsiveness for patients with improving rosacea.
目前尚无专门针对酒渣鼻的生活质量（QOL）评估工具。
我们旨在开发一种经过验证的、可靠的酒渣鼻专用评估工具。
通过6次深入访谈，我们编制了21个酒渣鼻专用条目。这些条目和Skindex-29在一个验证队列（n = 59）中进行了应用。分别用Cronbach's系数α和组内相关系数来测量内部一致性可靠性和可重复性。通过比较基线与4至6个月的反应来评估反应性。用主轴因子分析评估结构效度。通过另外38名患者比较酒渣鼻专用QOL评估工具和Skindex之间反应性的差异来检验区分效度。
可靠性较高（Cronbach'sα：0.82 - 0.97，组内相关系数：0.70 - 0.95）。酒渣鼻专用QOL评估工具对病情改善的患者显示出初步的反应性（P≤0.05）。主轴因子分析与假设量表相关（r = 0.57 - 0.82）。使用酒渣鼻专用QOL评估工具在反应性上有更大差异，说明了区分效度（P = 0.008）。
潜在的选择偏倚和缺乏普遍性是一个局限。
酒渣鼻专用QOL评估工具RosaQoL似乎是一种可靠且有效的QOL评估工具，对病情改善的酒渣鼻患者显示出初步的反应性。
