Yoshikawa Kazuko, Kokudo Naoki, Tanaka Masami, Nakano Tatsuro, Shibata Hirofumi, Aragaki Naokatsu, Higuchi Tomihiko, Hashimoto Toshihiro
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Chem Pharm Bull (Tokyo). 2008 Jan;56(1):89-92. doi: 10.1248/cpb.56.89.
From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
从石蕊中分离出两种新型枞酸型二萜类化合物，花冈烯醇A（1）和B（2）。在本次研究中，还分离出四种已知的枞酸型二萜类化合物（3 - 6）、四种已知的半日花烷型二萜类化合物（7 - 10）、一种已知的异海松烷型二萜类化合物（11）以及六种已知的芳香族化合物。这些结构主要通过广泛的核磁共振实验得以阐明。花冈烯醇A（1）是一种独特的枞酸型二萜，在杉醇的C - 6和C - 18之间存在醚键。花冈烯醇B（2）也是一种独特的裂环枞酸型二萜，具有γ - 内酯结构，该结构是由12 - 羟基脱氢枞醇的C - 6/C - 7之间裂解并随后氧化形成的。此外，对所有分离出的化合物（1 - 17）进行了抗耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE）的抗菌活性测试。
