Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, Campus de Fuente Nueva, s/n. 18071 Granada, Spain.
Molecules. 2012 Feb 6;17(2):1448-67. doi: 10.3390/molecules17021448.
Communic acids are diterpenes with labdane skeletons found in many plant species, mainly conifers, predominating in the genus Juniperus (fam. Cupresaceae). In this review we briefly describe their distribution and different biological activities (anti- bacterial, antitumoral, hypolipidemic, relaxing smooth muscle, etc.). This paper also includes a detailed explanation of their use as chiral building blocks for the synthesis of bioactive natural products. Among other uses, communic acids have proven useful as chirons for the synthesis of quassinoids (formal), abietane antioxidants, ambrox and other perfume fixatives, podolactone herbicides, etc., featuring shorter and more efficient processes.
通讯酸是具有拉伯烷骨架的二萜类化合物，存在于许多植物物种中，主要是针叶树，以 Juniperus 属（柏科）为主。在这篇综述中，我们简要描述了它们的分布和不同的生物活性（抗细菌、抗肿瘤、降血脂、松弛平滑肌等）。本文还详细介绍了它们作为手性砌块用于合成生物活性天然产物。除其他用途外，通讯酸已被证明可作为合成 quassinoids（正式）、abietane 抗氧化剂、 Ambrox 和其他香料固定剂、podolactone 除草剂等的手性砌块，具有更短、更有效的工艺。
