Zhao Pei Hua, Sun Li Mei, Liu Xiu Jin, Cao Mei Ai, Yuan Cheng Shan
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, People's Republic of China.
Chem Pharm Bull (Tokyo). 2008 Jan;56(1):102-4. doi: 10.1248/cpb.56.102.
Chemical investigation of the roots of Dictamnus radicis Cortex led to the isolation of a new limonoid isodictamdiol (1) and a known dictamdiol (2), the first 5S/9S-type degraded limonoids, together with other six known limonoids (3-8). The chemical structures were identified on the basis of modern spectroscopic methods, including IR, MS, NMR ((1)H-NMR, (13)C-NMR, (1)H-(1)H COSY, HMQC, HMBC, NOESY). Additionally, the absolute configurations of limonoid isodictamdiol (1) and dictamdiol (2) were separately elucidated by single crystal X-ray diffraction, as well as their circular dichroism spectra. Furthermore, all compounds were evaluated for antibacterial activity against three bacterial cultures.
对白鲜皮根部进行化学研究，从中分离出一种新的柠檬苦素类化合物异白鲜二醇（1）和一种已知的白鲜二醇（2），这是首次发现的5S/9S型降解柠檬苦素类化合物，同时还分离出其他六种已知的柠檬苦素类化合物（3 - 8）。通过现代光谱方法（包括红外光谱、质谱、核磁共振（氢谱、碳谱、氢氢相关谱、异核多量子相干谱、异核多键相关谱、核Overhauser效应谱））确定了化学结构。此外，通过单晶X射线衍射以及圆二色光谱分别阐明了柠檬苦素类化合物异白鲜二醇（1）和白鲜二醇（2）的绝对构型。此外，还对所有化合物针对三种细菌培养物的抗菌活性进行了评估。
