Grimwood K, Cohet C, Rich F J, Cheng S, Wood C, Redshaw N, Cunningham C W, Pearce N, Kirman J R
Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.
Epidemiol Infect. 2008 Oct;136(10):1333-41. doi: 10.1017/S0950268807000180. Epub 2008 Jan 4.
This study assessed risk factors for respiratory syncytial virus (RSV) hospitalization and disease severity in Wellington, New Zealand. During the southern hemisphere winter months of 2003--2005, 230 infants aged < 24 months hospitalized with bronchiolitis were recruited. RSV was indentified in 141 (61%) infants. Comparison with data from all live hospital births from the same region (2003--2005) revealed three independent risk factors for RSV hospitalization: birth between February and July [adjusted risk ratio (aRR) 1.62, 95% confidence interval (CI) 1.5-2.29], gestation <37 weeks (aRR 2.29, 95% CI 1.48-3.56) and Māori ethnicity (aRR 3.64, 95% CI 2.27-5.85), or Pacific ethnicity (aRR 3.60, 95% CI 2.14-6.06). The high risk for Māori and Pacific infants was only partially accounted for by other known risk factors. This work highlights the importance of RSV disease in indigenous and minority populations, and identifies the need for further research to develop public health measures that can reduce health disparities.
本研究评估了新西兰惠灵顿呼吸道合胞病毒（RSV）住院治疗及疾病严重程度的风险因素。在2003年至2005年南半球冬季期间，招募了230名年龄小于24个月因细支气管炎住院的婴儿。141名（61%）婴儿检测出RSV。与同一地区（2003年至2005年）所有活产医院出生数据比较，发现RSV住院治疗的三个独立风险因素：2月至7月出生[调整风险比（aRR）1.62，95%置信区间（CI）1.5 - 2.29]、妊娠小于37周（aRR 2.29，95%CI 1.48 - 3.56）以及毛利族裔（aRR 3.64，95%CI 2.27 - 5.85），或太平洋族裔（aRR 3.60，95%CI 2.14 - 6.06）。毛利族和太平洋族裔婴儿的高风险仅部分由其他已知风险因素解释。这项工作突出了RSV疾病在原住民和少数族裔人群中的重要性，并确定需要进一步研究以制定可减少健康差距的公共卫生措施。
