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银屑病的病理生理学:白细胞介素-23和辅助性T细胞17细胞因子的最新进展

Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines.

作者信息

Fitch Erin, Harper Erin, Skorcheva Iliyana, Kurtz Stephen E, Blauvelt Andrew

机构信息

Dermatology Service, Veterans Affairs Medical Center, 3710 Southwest US Veterans Hospital Road, Mail Code R&D 55, Portland, OR 97239, USA.

出版信息

Curr Rheumatol Rep. 2007 Dec;9(6):461-7. doi: 10.1007/s11926-007-0075-1.

Abstract

T helper (Th) 17 cells, a novel T-cell subset, have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases. Interleukin (IL)-23 stimulates survival and proliferation of Th17 cells, and thus serves as a key master cytokine regulator for these diseases. In psoriasis, IL-23 is overproduced by dendritic cells and keratinocytes, and this cytokine stimulates Th17 cells within dermis to make IL-17A and IL-22. IL-22, in particular, drives keratinocyte hyperproliferation in psoriasis. Future targeting of these key cytokines is likely to lead to dramatic clinical improvement in patients with psoriasis. This review focuses on the numerous recent studies on the roles of IL-23 and Th17 cells in the pathogenesis of psoriasis.

摘要

辅助性T(Th)17细胞是一种新型T细胞亚群,与银屑病及其他自身免疫性炎症性疾病的发病机制有关。白细胞介素(IL)-23可刺激Th17细胞存活和增殖,因此是这些疾病的关键主要细胞因子调节因子。在银屑病中,树突状细胞和角质形成细胞过度产生IL-23,这种细胞因子刺激真皮内的Th17细胞产生IL-17A和IL-22。特别是IL-22可促使银屑病中的角质形成细胞过度增殖。未来针对这些关键细胞因子进行治疗可能会使银屑病患者的临床症状得到显著改善。本综述重点关注了近期关于IL-23和Th17细胞在银屑病发病机制中作用的众多研究

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本文引用的文献

2
Phenotypic and functional features of human Th17 cells.
J Exp Med. 2007 Aug 6;204(8):1849-61. doi: 10.1084/jem.20070663. Epub 2007 Jul 16.
4
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.
Nature. 2007 Jul 26;448(7152):480-3. doi: 10.1038/nature05969. Epub 2007 Jun 20.
5
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Nature. 2007 Jul 26;448(7152):484-487. doi: 10.1038/nature05970. Epub 2007 Jun 20.
6
7
IL-17 attenuates the anti-apoptotic effects of GM-CSF in human neutrophils.
Mol Immunol. 2008 Jan;45(1):160-8. doi: 10.1016/j.molimm.2007.04.027. Epub 2007 Jun 6.
8
Interleukin-21: a new modulator of immunity, infection, and cancer.
Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):223-32. doi: 10.1016/j.cytogfr.2007.04.003. Epub 2007 May 16.
9
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Nat Immunol. 2007 Jun;8(6):639-46. doi: 10.1038/ni1467. Epub 2007 May 7.

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