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2
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本文引用的文献

1
Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program.Fli1和Ets1在结缔组织生长因子/CCN2基因调控以及促纤维化基因程序的诱导中具有不同作用。
J Biol Chem. 2006 Sep 1;281(35):25259-69. doi: 10.1074/jbc.M600466200. Epub 2006 Jul 6.
2
beta-Catenin regulates the expression of tenascin-C in human colorectal tumors.β-连环蛋白调节人结肠直肠癌中肌腱蛋白-C的表达。
Oncogene. 2005 Dec 8;24(55):8200-4. doi: 10.1038/sj.onc.1208960.
3
Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).人类α2（I）型胶原基因（COL1A2）第一内含子中一种阻遏物的鉴定。
J Biol Chem. 2005 Oct 21;280(42):35417-23. doi: 10.1074/jbc.M502681200. Epub 2005 Aug 8.
4
GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts.GATA-4与人类α2（I）胶原蛋白基因（COL1A2）的上游元件结合，并抑制成纤维细胞中的转录。
Matrix Biol. 2005 Aug;24(5):333-40. doi: 10.1016/j.matbio.2005.06.001.
5
GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells.GATA-6调节促进血管平滑肌细胞合成功能的基因。
Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):309-14. doi: 10.1161/01.ATV.0000152725.76020.3c. Epub 2004 Dec 9.
6
Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1.转化生长因子-β上调人皮肤成纤维细胞中的腱生蛋白-C涉及Smad3、Sp1和Ets1。
Oncogene. 2004 Mar 4;23(9):1656-67. doi: 10.1038/sj.onc.1207064.
7
Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis.上皮分化决定因子GATA在卵巢肿瘤发生中的异常表达。
Cancer Res. 2003 Aug 15;63(16):4967-77.
8
Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin.在纤维化硬皮病皮肤中，胶原蛋白转录抑制因子Fli1持续下调。
Am J Pathol. 2003 Aug;163(2):571-81. doi: 10.1016/S0002-9440(10)63685-1.
9
Tenascins: regulation and putative functions during pathological stress.腱生蛋白：病理应激过程中的调控及假定功能
J Pathol. 2003 Jul;200(4):488-99. doi: 10.1002/path.1415.
10
FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration.粘着斑激酶（FAK）诱导1型硫氧还蛋白（Prx1）的表达，以促进肌腱蛋白-C依赖的成纤维细胞迁移。
J Cell Biol. 2003 Apr 28;161(2):393-402. doi: 10.1083/jcb.jcb.200302126.

GATA-6是成纤维细胞中人腱生蛋白-C基因表达的一种新型转录抑制因子。

GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts.

作者信息

Ghatnekar Angela, Trojanowska Maria

机构信息

Division of Rheumatology and Immunology, Medical University of South Carolina, CSB 912, SC 29425-2229, USA.

出版信息

Biochim Biophys Acta. 2008 Mar;1779(3):145-51. doi: 10.1016/j.bbagrm.2007.11.012. Epub 2007 Dec 14.

DOI:10.1016/j.bbagrm.2007.11.012
PMID:18177748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2295212/
Abstract

In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-beta-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position -467 to -460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.

摘要

在本研究中，我们证明GATA-6是TN-C基因表达的一种新型抑制因子。我们证实，在成纤维细胞中过表达GATA-6可抑制基础水平，并显著降低IL-4和TGF-β诱导的TN-C mRNA及蛋白水平。一个GATA-6反应元件被定位到TN-C启动子的-467至-460位。此外，我们还表明GATA-6在体外和体内均能结合该位点。