GATA-6是成纤维细胞中人腱生蛋白-C基因表达的一种新型转录抑制因子。
GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts.
作者信息
Ghatnekar Angela, Trojanowska Maria
机构信息
Division of Rheumatology and Immunology, Medical University of South Carolina, CSB 912, SC 29425-2229, USA.
出版信息
Biochim Biophys Acta. 2008 Mar;1779(3):145-51. doi: 10.1016/j.bbagrm.2007.11.012. Epub 2007 Dec 14.
Abstract
In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-beta-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position -467 to -460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.
摘要
在本研究中，我们证明GATA-6是TN-C基因表达的一种新型抑制因子。我们证实，在成纤维细胞中过表达GATA-6可抑制基础水平，并显著降低IL-4和TGF-β诱导的TN-C mRNA及蛋白水平。一个GATA-6反应元件被定位到TN-C启动子的-467至-460位。此外，我们还表明GATA-6在体外和体内均能结合该位点。
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