白细胞介素-17受体中的结构-功能关系：对信号转导和治疗的启示
Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.
作者信息
Shen Fang, Gaffen Sarah L
机构信息
Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
出版信息
Cytokine. 2008 Feb;41(2):92-104. doi: 10.1016/j.cyto.2007.11.013. Epub 2008 Jan 4.
Abstract
IL-17 is the defining cytokine of a newly-described "Th17" population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its function or molecular biology. However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, which will be reviewed here.
摘要
白细胞介素-17是新描述的“Th17”细胞群的标志性细胞因子，在介导炎症和自身免疫中起关键作用。白细胞介素-17/白细胞介素-17受体超家族是最近描述的一类细胞因子和受体，直到最近人们对其功能或分子生物学了解甚少。然而，在过去一年里，人们对受体复合物的组成和动态以及下游信号转导机制有了重要的新见解，本文将对此进行综述。
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