Zaidi Nousheen, Kalbacher Hubert
Medical and Natural Sciences Research Centre, University of Tübingen, Ob dem Himmelreich 7, 72074 Tuebingen, Germany.
Biochem Biophys Res Commun. 2008 Mar 14;367(3):517-22. doi: 10.1016/j.bbrc.2007.12.163. Epub 2008 Jan 4.
Cathepsin E is a major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway. In the present review some of the known features of cathepsin E such as tissue distribution, subcellular localization, enzymatic properties, intracellular trafficking, gene regulation and associated physiological conditions are highlighted.
组织蛋白酶E是一种主要的细胞内天冬氨酸蛋白酶，主要存在于免疫系统细胞中，常通过主要组织相容性复合体II类途径参与抗原加工。在本综述中，重点介绍了组织蛋白酶E的一些已知特性，如组织分布、亚细胞定位、酶学性质、细胞内运输、基因调控及相关生理状况。
