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《苏木中的新卡山二萜及其抗疟活性》

New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity.

机构信息

Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China.

出版信息

Molecules. 2017 Oct 17;22(10):1751. doi: 10.3390/molecules22101751.

DOI:10.3390/molecules22101751
PMID:29039768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6151731/
Abstract

One new cassane diterpene possessing an unusual bridge between C-19 and C-20 named caesalsappanin R (), as well as another new diterpene caesalsappanin S (), were isolated from the seeds of with methanol extract. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Their biological activities were profiled by their antiplasmodial activity.

摘要

从 with 的甲醇提取物中分离得到了一种具有 C-19 和 C-20 之间不寻常桥接的新型贝壳杉二萜 caesalsappanin R (),以及另一种新型二萜 caesalsappanin S ()。通过光谱分析确定了它们的结构,并与之前研究的数据进行了比较。通过抗疟活性对它们的生物活性进行了分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f117/6151731/296539dae02a/molecules-22-01751-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f117/6151731/5fb55dca4769/molecules-22-01751-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f117/6151731/296539dae02a/molecules-22-01751-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f117/6151731/5fb55dca4769/molecules-22-01751-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f117/6151731/296539dae02a/molecules-22-01751-g002.jpg

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A Comprehensive Review on Bioactive Compounds Found in .关于 中发现的生物活性化合物的综合综述。
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