来自苏木种子仁的决明烷二萜类化合物。
Cassane diterpenes from the seed kernels of Caesalpinia sappan.
作者信息
Nguyen Hai Xuan, Nguyen Nhan Trung, Dang Phu Hoang, Thi Ho Phuoc, Nguyen Mai Thanh Thi, Van Can Mao, Dibwe Dya Fita, Ueda Jun-Ya, Awale Suresh
机构信息
Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
出版信息
Phytochemistry. 2016 Feb;122:286-293. doi: 10.1016/j.phytochem.2015.12.018. Epub 2016 Jan 5.
Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.
从越南苏木的种子仁中分离出了8种结构各异的决明烷二萜，命名为托莫辛A - H。通过广泛的核磁共振（NMR）和圆二色（CD）光谱分析确定了它们的结构。在分离出的化合物中，托莫辛A、番荔枝宁A、F和H在营养缺乏条件下对PANC - 1人胰腺癌细胞表现出轻度的优先细胞毒性，而在营养丰富的正常条件下不产生毒性。
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