来自苏木种子的具有氧桥的决明烷二萜类化合物。
Cassane diterpenes with oxygen bridge from the seeds of Caesalpinia sappan.
作者信息
Xu Xudong, Yuan Jingquan, Zhou Xingyang, Li Weiping, Zhu Nailiang, Wu Haifeng, Li Pengfei, Sun Zhonghao, Yang Junshan, Ma Guoxu
机构信息
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
出版信息
Fitoterapia. 2016 Jul;112:205-10. doi: 10.1016/j.fitote.2016.06.005. Epub 2016 Jun 14.
The seeds of the medicinal plant Caesalpinia sappan yielded fourteen cassane-type diterpenes, including six new rearranged ones named as caesalppans A-F (1-6). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated new compounds 1-6 possess lactone-type cassane diterpenoid skeleton with an oxygen bridge between C-19 and C-20, and were tested cytotoxic activity against four cancer cell lines using the MTT method.
药用植物苏木的种子产生了14种决明烷型二萜，其中包括6种新的重排二萜，命名为苏木烷A-F（1-6）。通过光谱分析并与文献数据比较确定了它们的结构。分离得到的新化合物1-6具有内酯型决明烷二萜骨架，在C-19和C-20之间有一个氧桥，并采用MTT法测试了其对四种癌细胞系的细胞毒性活性。
Zotero 插件