Wong Kurt A, Rodriguez Ana
Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA.
J Immunol. 2008 Jan 15;180(2):716-26. doi: 10.4049/jimmunol.180.2.716.
During an acute Plasmodium infection, uncontrolled proinflammatory responses can cause morbidity and mortality. Regulation of this response is required to prevent immunopathology. We therefore decided to investigate a recently characterized subset of regulatory dendritic cells (DCs) that expresses low levels of CD11c and high levels of CD45RB. During a Plasmodium yoelii infection, these regulatory CD11clowCD45RBhigh DCs become the prevalent CD11c-expressing cells in the spleen, overtaking the conventional CD11chigh DCs. Furthermore, the regulatory CD11clowCD45RBhigh DCs induce IL-10-expressing CD4 T cells. A similar change in splenic DC subsets is seen when mice are injected with sublethal doses of LPS, suggesting that shifting the splenic DC subsets in favor of regulatory CD11clowCD45RBhigh DCs can be triggered solely by a high inflammatory stimulus. This is the first time regulatory DCs have been observed in a natural immune response to an infectious disease or endotoxic shock.
在急性疟原虫感染期间，不受控制的促炎反应可导致发病和死亡。需要调节这种反应以防止免疫病理。因此，我们决定研究最近鉴定出的一个调节性树突状细胞（DC）亚群，其表达低水平的CD11c和高水平的CD45RB。在约氏疟原虫感染期间，这些调节性CD11clowCD45RBhigh DC成为脾脏中表达CD11c的主要细胞，超过了传统的CD11chigh DC。此外，调节性CD11clowCD45RBhigh DC诱导表达IL-10的CD4 T细胞。当给小鼠注射亚致死剂量的LPS时，脾脏DC亚群会出现类似变化，这表明仅由高炎症刺激就可触发脾脏DC亚群向有利于调节性CD11clowCD45RBhigh DC的方向转变。这是首次在对传染病或内毒素休克的天然免疫反应中观察到调节性DC。
