Kotwal Vikram, Bhise Kiran, Thube Rahul
MCE Society's Allana College of Pharmacy, Camp, Pune-01, Maharashtra, India.
AAPS PharmSciTech. 2007 Dec 28;8(4):E120. doi: 10.1208/pt0804120.
The purpose of the present study was to explore the passive and electrically assisted transdermal transport of diphenhydramine hydrochloride (DPH) by iontophoresis. For better bioavailability, better patient compliance, and enhanced delivery of DPH, an iontophoretic drug delivery system of a thermosensitive DPH gel was formulated using Lutrol F-127. The study was conducted using silver-silver chloride electrodes across hairless pig skin. The effects of pH, polymer concentration, electrode design, and pulse rate on the DPH permeation were investigated. The relationship between temperature, viscosity, and conductance of DPH was correlated using conductometry. Iontophoretic transport of DPH was found to increase with a decrease in the pH of the medium and an increase in the surface area of the electrode. Viscosity measurements and flux calculations indicated the suitability of the Lutrol gel for transdermal iontophoretic delivery of DPH. Anodal pulsed iontophoresis with disc electrode significantly increased the DPH skin permeation as compared with the passive controls.
本研究的目的是通过离子电渗疗法探索盐酸苯海拉明（DPH）的被动和电辅助透皮转运。为了获得更好的生物利用度、更好的患者依从性并增强DPH的递送，使用聚氧乙烯蓖麻油F-127制备了热敏性DPH凝胶的离子电渗给药系统。该研究使用氯化银电极在无毛猪皮肤上进行。研究了pH值、聚合物浓度、电极设计和脉冲频率对DPH渗透的影响。通过电导测量法关联了DPH的温度、粘度和电导率之间的关系。发现DPH的离子电渗转运随着介质pH值的降低和电极表面积的增加而增加。粘度测量和通量计算表明聚氧乙烯蓖麻油凝胶适用于DPH的透皮离子电渗递送。与被动对照组相比，使用圆盘电极的阳极脉冲离子电渗疗法显著增加了DPH的皮肤渗透。
