Truong D D, Sandroni P, van den Noort S, Matsumoto R R
Department of Neurology, University of California, Irvine, USA.
Arch Neurol. 1995 Apr;52(4):405-7. doi: 10.1001/archneur.1995.00540280095022.
To assess the effectiveness of diphenhydramine hydrochloride (Benadryl) in the treatment of patients with idiopathic truncal dystonia.
Before-and-after trial.
University referral center.
Five consecutive patients with idiopathic truncal dystonia who were poorly treated with conventional pharmacotherapies. No patients were withdrawn from the trial for adverse side effects.
Treatments with diphenhydramine hydrochloride (50 mg intravenously or up to 500 mg/kg orally). Follow-up for up to 20 months.
Dystonia evaluation.
Diphenhydramine therapy was associated with minimal side effects, and it was most effective in treating patients with dystonia who experienced lightning jerks. Treatment with intravenous diphenhydramine may have a predictive value on a future response to oral therapy.
Diphenhydramine should be considered a therapeutic option for idiopathic truncal dystonia with lightning jerks.
评估盐酸苯海拉明（苯那君）治疗特发性躯干肌张力障碍患者的疗效。
前后对照试验。
大学转诊中心。
连续5例接受传统药物治疗效果不佳的特发性躯干肌张力障碍患者。无患者因不良反应退出试验。
使用盐酸苯海拉明治疗（静脉注射50毫克或口服高达500毫克/千克）。随访长达20个月。
肌张力障碍评估。
苯海拉明治疗副作用极小，对伴有闪电样抽搐的肌张力障碍患者疗效最佳。静脉注射苯海拉明治疗可能对未来口服治疗的反应具有预测价值。
对于伴有闪电样抽搐的特发性躯干肌张力障碍，应考虑将苯海拉明作为一种治疗选择。
