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Cryptosporidial infections in SCID mice reconstituted with human or murine lymphocytes.

作者信息

Mead J R, Arrowood M J, Healey M C, Sidwell R W

机构信息

Animal, Dairy and Veterinary Sciences Department, Utah State University, Logan 84322.

出版信息

J Protozool. 1991 Nov-Dec;38(6):59S-61S.

PMID:1818204
Abstract

Severe combined immunodeficient (SCID) mice were experimentally infected with Cryptosporidium parvum. Adoptive transfer of BALB/c thymocytes, spleen and bone marrow cells resulted in functional immunologic reconstitution followed by complete eradication of the cryptosporidial infection. Additional SCID mice were injected with human blood peripheral blood lymphocytes and were subsequently infected with C. parvum. The latter mice (SCID-hu-PBL) were at least partially reconstituted with human lymphoid tissues, as evidenced by flow cytometric identification of human cell populations in the SCID mouse spleens and the response of these cells to the T-cell mitogen phytohemagglutinin. The SCID-hu-PBL mice did not resolve the cryptosporidial infections, although a transient reduction in parasitemia was noted 4-6 wk post-reconstitution.

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