Liu T C, Chan Y C, Han P
Division of Laboratory Hematology, National University Hospital, Singapore.
Southeast Asian J Trop Med Public Health. 1991 Sep;22(3):332-6.
Secondary dengue fever as dengue hemorrhagic fever or dengue shock syndrome is a potentially fatal complication of an infection that presents with few clinical signs that help in the diagnosis. Previous workers have reported the value of buffy coat determinations of atypical lymphocytes as an aid to the diagnosis. We report here the use of an automated white blood cell differential counter, the Technicon H1 in the monitoring of the atypical lymphocyte count as a measure of the progress of the infection in a retrospective study of serial full blood counts in 45 serologically confirmed patients. Technicon H1 'basophil' and large unstained cell counts and manual atypical lymphocyte counts rose in tandem with the drop in platelets and decreased when the platelets recovered. In a sub-study, the atypical lymphocytes were immunophenotyped and found to be predominantly derived from T lymphocytes. We conclude that the Technicon H*1 is a useful monitor of the activity of the infection in dengue hemorrhagic fever.
作为登革出血热或登革休克综合征的继发性登革热是一种感染的潜在致命并发症，其临床表现很少有助于诊断。以前的研究人员报告了通过测定血沉棕黄层中的非典型淋巴细胞来辅助诊断的价值。我们在此报告，在一项对45例血清学确诊患者的系列全血细胞计数的回顾性研究中，使用自动白细胞分类计数器Technicon H1监测非典型淋巴细胞计数，以此作为感染进展的一项指标。Technicon H1的“嗜碱性粒细胞”和大型未染色细胞计数以及手工计数的非典型淋巴细胞计数随着血小板数量下降而同步上升，而在血小板恢复时则下降。在一项子研究中，对非典型淋巴细胞进行了免疫表型分析，发现它们主要来源于T淋巴细胞。我们得出结论，Technicon H*1是监测登革出血热感染活动的一种有用工具。
