阿普拉明纳：一种从黑指纹海兔中分离出的新型细胞毒性胺类物质。
Aplaminal: a novel cytotoxic aminal isolated from the sea hare Aplysia kurodai.
作者信息
Kuroda Takeshi, Kigoshi Hideo
机构信息
Department of Chemistry, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8571, Japan.
出版信息
Org Lett. 2008 Feb 7;10(3):489-91. doi: 10.1021/ol7029307. Epub 2008 Jan 10.
PMID:18184001
Abstract
Aplaminal (1), a novel triazabicyclo[3.2.1]octane framework metabolite, has been isolated from the sea hare Aplysia kurodai. The structure was determined by analysis of NMR data and confirmed by single-crystal X-ray diffraction analysis. Aplaminal (1) exhibits cytotoxicity against Hela S3 cells.
摘要
从日本黑兔海兔中分离出了一种新型的三氮杂双环[3.2.1]辛烷骨架代谢产物阿普拉明（1）。通过核磁共振数据的分析确定了其结构，并通过单晶X射线衍射分析得到证实。阿普拉明（1）对海拉S3细胞具有细胞毒性。
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