Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
J Nat Prod. 2010 Jan;73(1):27-32. doi: 10.1021/np900627r.
Seven new (1-7) and seven previously reported (8-14) halogenated metabolites were isolated from the organic extract of the Brazilian red alga Laurencia catarinensis. The structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed NMR and MS spectroscopic analyses, whereas the structure of metabolite 6 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of metabolite 1 was determined using the modified Mosher's method. The in vitro cytotoxicity of compounds 1-14 was evaluated against HT29, MCF7, and A431 cell lines.
从巴西红藻卡廷加烯中提取的有机提取物中分离出了七种新的（1-7）和七种先前报道的（8-14）卤代代谢物。新天然产物的结构阐明和相对构型的分配是基于详细的 NMR 和 MS 光谱分析，而代谢物 6 的结构则通过单晶 X 射线衍射分析得到证实。代谢物 1 的绝对构型使用改进的 Mosher 法确定。对化合物 1-14 进行了体外细胞毒性测试，评估了它们对 HT29、MCF7 和 A431 细胞系的活性。
