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明尼苏达州和威斯康星州素食者及新入院成年人粪便中耐抗菌药物大肠杆菌的预测因素。

Predictors of antimicrobial-resistant Escherichia coli in the feces of vegetarians and newly hospitalized adults in Minnesota and Wisconsin.

作者信息

Sannes Mark R, Belongia Edward A, Kieke Burney, Smith Kirk, Kieke Amy, Vandermause Mary, Bender Jeff, Clabots Connie, Winokur Patricia, Johnson James R

机构信息

Infectious Diseases Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.

出版信息

J Infect Dis. 2008 Feb 1;197(3):430-4. doi: 10.1086/525530.

Abstract

To determine whether poultry contact/consumption predicts colonization with antimicrobial-resistant Escherichia coli, 567 newly hospitalized patients and 100 vegetarians were assessed microbiologically and epidemiologically. Multivariable analysis showed that poultry contact/consumption, other dietary habits, and antimicrobial use did not significantly predict resistance. In contrast, foreign travel significantly predicted both trimethoprim-sulfamethoxazole resistance (prevalence ratio, 2.7 [95% confidence interval, 1.3-5.6]) and "any resistance" (total population), whereas intensive-care-unit exposure predicted any resistance (hospital patients). Thus, most of the individual-level exposures-including poultry contact/consumption-that had been expected to be significant risk factors for infection with antimicrobial-resistant E. coli did not prove to be such. Other exposures, including household-, community-, and population-level effects, may be more important.

摘要

为了确定接触/食用家禽是否会增加耐抗菌药物大肠杆菌定植的风险,我们对567名新入院患者和100名素食者进行了微生物学和流行病学评估。多变量分析显示,接触/食用家禽、其他饮食习惯以及抗菌药物的使用并不能显著预测耐药性。相比之下,出国旅行是预测甲氧苄啶-磺胺甲恶唑耐药性(患病率比,2.7 [95%置信区间,1.3 - 5.6])和“任何耐药性”(总体人群)的显著因素,而入住重症监护病房是预测“任何耐药性”(住院患者)的显著因素。因此,大多数个体层面的暴露因素,包括接触/食用家禽,原本被认为是感染耐抗菌药物大肠杆菌的重要风险因素,但事实并非如此。其他暴露因素,包括家庭、社区和人群层面的影响,可能更为重要。

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