Jayasinghe Y, Grover S R, Zacharin M
Department of Gynaecology Royal Children's Hospital, Melbourne, Victoria, Australia.
BJOG. 2008 Feb;115(3):304-15. doi: 10.1111/j.1471-0528.2007.01601.x.
Anorexia nervosa (AN) initiates an adaptive response at the level of the hypothalamus, which results in a complex interplay involving most elements of the neuroendocrine axis. Consequences of onset of disease in adolescence include amenorrhoea, pubertal arrest with potential loss of target height, and osteoporosis with reduced capacity for future attainment of peak bone mass. With recovery, delay in restoration of menses is common. Hormonal therapies for restoration of bone mineral density (BMD) in adolescents have shown limited efficacy. This review will discuss the reproductive endocrine effects of AN in adolescence, and discuss new investigative tools for monitoring restoration of reproductive function and BMD in this population.
神经性厌食症（AN）在下丘脑水平引发一种适应性反应，这会导致涉及神经内分泌轴大多数元素的复杂相互作用。青春期发病的后果包括闭经、青春期停滞以及潜在的目标身高丧失，还有骨质疏松，导致未来达到峰值骨量的能力降低。随着病情恢复，月经恢复延迟很常见。用于恢复青少年骨矿物质密度（BMD）的激素疗法疗效有限。本综述将讨论AN在青春期对生殖内分泌的影响，并探讨监测该人群生殖功能和BMD恢复情况的新研究工具。
