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由gtcA介导的磷壁酸糖基化对于噬菌体吸附和单核细胞增生李斯特菌4b血清型的易感性是必需的。

Teichoic acid glycosylation mediated by gtcA is required for phage adsorption and susceptibility of Listeria monocytogenes serotype 4b.

作者信息

Cheng Ying, Promadej Nattawan, Kim Jae-Won, Kathariou S

机构信息

North Carolina State University, Department of Food Science, Raleigh, NC 27695-7624, USA.

出版信息

Appl Environ Microbiol. 2008 Mar;74(5):1653-5. doi: 10.1128/AEM.01773-07. Epub 2008 Jan 11.

Abstract

An insertion mutant of gtcA, responsible for serotype-specific glycosylation of the cell wall teichoic acid in serotype 4b strains of Listeria monocytogenes, was also resistant to both Listeria genus- and serotype 4b-specific phages. The sugar substituents on teichoic acid appeared essential for the adsorption of phages A500 (serotype 4b specific) and A511 (Listeria genus specific) to serotype 4b L. monocytogenes.

摘要

gtcA的一个插入突变体负责单核细胞增生李斯特菌4b血清型菌株细胞壁磷壁酸的血清型特异性糖基化,它对李斯特菌属特异性噬菌体和4b血清型特异性噬菌体均具有抗性。磷壁酸上的糖取代基似乎是噬菌体A500(4b血清型特异性)和A511(李斯特菌属特异性)吸附到4b血清型单核细胞增生李斯特菌上所必需的。

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