Krcméry V, Lesicka M, Blahova J, Schäfer V
Institute of Preventive and Clinical Medicine, Bratislava, Czechoslovakia.
J Chemother. 1991 Dec;3(6):363-6. doi: 10.1080/1120009x.1991.11739121.
Determinants of resistance of imipenem can be, in Pseudomonas aeruginosa strains resistant to this drug, transferred by transduction with wild-type phages as well as mobilized for conjugal transfer, as demonstrated by the indirect selection procedure. Exconjugants obtained in the latter type of experiments do not transfer imipenem resistance determinant to further recipient strains(s) by conjugation. Mobilized imipenem resistance is of non-hydrolytic character and its biochemical mechanism is unknown at present.
在对亚胺培南耐药的铜绿假单胞菌菌株中，亚胺培南耐药的决定因素可通过野生型噬菌体转导进行转移，也可通过间接选择程序证明其可被动员用于接合转移。在后一种类型的实验中获得的接合子不会通过接合将亚胺培南耐药决定因素转移到其他受体菌株。被动员的亚胺培南耐药具有非水解特性，其生化机制目前尚不清楚。
