雌激素对大鼠子宫中前列腺素F与E相互转化的影响（作者译）

[Effect of estrogen on interconversion of prostaglandin F and E in rat uterus (author's transl)].

作者信息

Kogo H, Aizawa Y

出版信息

Nihon Yakurigaku Zasshi. 1977 Nov;73(8):871-6. doi: 10.1254/fpj.73.871.

DOI:10.1254/fpj.73.871

Abstract

To determine estrogen action in PG metabolism in rat uterus, effect of the hormone on the uptake and interconversion of PGF and E was studied using 3H-PGF2alpha and 3H-PGE2. The following results were obtained: Uptake of 3H-PGF2alpha and 3H-PGE2 was increased at 6 hours after estrogen injection. The conversion into PGF and PGE group from 3H-PGE2 and 3H-PGF2alpha, respectively, was observed in rat uterus, but the hormone action on the interconversion of PG was apparently different between PGF2alpha and PGE2. The conversion of 3H-PGF2alpha into PGE group was increased with the lapse of time after estrogen injection. However, estrogen action on the conversion of 3H-PGE2 into PGF group was not so remarkable as that of 3H-PGF2alpha. Effects of indomethacin in vivo and in vitro on the metabolism of PGF2alpha increased by estrogen were also examined. Estrogen action on the uptake of PGF group was inhibited by indomethacin injection, but the conversion into PGE was not influenced by this compound.

摘要

为了确定雌激素在大鼠子宫前列腺素（PG）代谢中的作用，使用³H-PGF₂α和³H-PGE₂研究了该激素对PGF和PGE摄取及相互转化的影响。得到以下结果：雌激素注射后6小时，³H-PGF₂α和³H-PGE₂的摄取增加。在大鼠子宫中观察到³H-PGE₂和³H-PGF₂α分别转化为PGF和PGE组，但激素对PG相互转化的作用在PGF₂α和PGE₂之间明显不同。雌激素注射后，³H-PGF₂α向PGE组的转化随时间推移而增加。然而，雌激素对³H-PGE₂转化为PGF组的作用不如³H-PGF₂α显著。还研究了吲哚美辛体内和体外对雌激素增加的PGF₂α代谢的影响。吲哚美辛注射可抑制雌激素对PGF组摄取的作用，但该化合物对其转化为PGE没有影响。