Castañeda-Ibarra F, Ruíz-Maya L, Campos-Rodríguez R, García Latorre E
Depto. de Bioquímica Aplicada, Escuela Superior de Medicina, I.P.N., México, D.F.
Arch Invest Med (Mex). 1991 Jan-Mar;22(1):13-7.
In the course of tissue invasion by the amoeba, cellular immune responses are generated with the production of lymphokines by T lymphocytes that could induce activation of B cells. Therefore, it is possible that besides the induction of B lymphocytes specific for amoebic antigens, there could be activation of B cells with different specificities, that is, polyclonal in nature. IgM antibodies against some natural and synthetic antigens were quantified in both sera from amoebic hepatic abscess (AHA) patients and healthy controls by means of an ELISA. Titers in each case analyzed were significantly higher in AHA patients than in controls. Results indicate that there is polyclonal activation of B lymphocytes in this disease.
在变形虫侵袭组织的过程中，T淋巴细胞产生淋巴因子，引发细胞免疫反应，进而诱导B细胞活化。因此，除了诱导针对阿米巴抗原的特异性B淋巴细胞外，还可能激活具有不同特异性的B细胞，即本质上为多克隆激活。通过酶联免疫吸附测定法（ELISA）对阿米巴肝脓肿（AHA）患者血清和健康对照血清中针对某些天然和合成抗原的IgM抗体进行了定量分析。结果显示，AHA患者每种情况下的抗体滴度均显著高于对照组。结果表明，该疾病中存在B淋巴细胞的多克隆激活。
