Schmitz Kathryn H, Warren Meghan, Rundle Andrew G, Williams Nancy I, Gross Myron D, Kurzer Mindy S
Division of Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA.
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):220-3. doi: 10.1158/1055-9965.EPI-07-0058.
The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. Exercise effects on these variables could mediate observed associations of exercise with hormonally related cancers, including breast cancer. The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women.
Fifteen sedentary premenopausal women (18-25 years) participated. Pre- and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F(2)-isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16-alpha-hydroxyestrone, and ratios of these metabolites (2:16, 2:4). Body composition was measured by dual-energy X-ray absorptiometry, and F(2)-isoprostanes and estrogens were measured by gas chromatography-mass spectrometry.
Aerobic exercise resulted in a 34% decrease in F(2)-isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). No significant changes were noted in estrogens.
The effect of exercise training on oxidative stress may be relevant to risk for hormonally related cancers.
运动训练对绝经前女性脂质过氧化和内源性雌激素的影响尚未完全明确。运动对这些变量的影响可能介导了运动与激素相关癌症（包括乳腺癌）之间已观察到的关联。本研究的目的是确定15周有氧运动对年轻、健康、月经正常女性的脂质过氧化、内源性雌激素和身体成分的影响。
15名久坐不动的绝经前女性（18 - 25岁）参与了研究。运动训练前后的尿液收集（三个24小时样本）在最近一次运动 session 后48小时开始，用于分析脂质过氧化标志物（F(2)-异前列腺素）和内源性雌激素，包括2-羟基雌激素、4-羟基雌激素、16-α-羟基雌酮以及这些代谢物的比率（2:16、2:4）。通过双能X线吸收法测量身体成分，通过气相色谱-质谱法测量F(2)-异前列腺素和雌激素。
有氧运动使F(2)-异前列腺素降低了34%（P = 0.02），体能提高了10%（P = 0.004），体重减轻了1.2千克（P = 0.007），脂肪量减少了1.8千克（P = 0.04）。雌激素未观察到显著变化。
运动训练对氧化应激的影响可能与激素相关癌症的风险有关。
