Friedenreich Christine M, Pialoux Vincent, Wang Qinggang, Shaw Eileen, Brenner Darren R, Waltz Xavier, Conroy Shannon M, Johnson Rhys, Woolcott Christy G, Poulin Marc J, Courneya Kerry S
Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada; Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Inter-University Laboratory of Human Movement Biology , Université Claude Bernard Lyon 1, University of Lyon , Villeurbanne , France.
BMJ Open Sport Exerc Med. 2016 Oct 24;2(1):e000171. doi: 10.1136/bmjsem-2016-000171. eCollection 2016.
Oxidative stress may contribute to cancer aetiology through several mechanisms involving damage to DNA, proteins and lipids leading to genetic mutations and genomic instability. The objective of this study was to determine the effects of aerobic exercise on markers of oxidative damage and antioxidant enzymes in postmenopausal women.
The Alberta Physical Activity and Breast Cancer Prevention Trial (ALPHA) was a two-centre, two-armed randomised trial of 320 inactive, healthy, postmenopausal women aged 50-74 years. Participants were randomly assigned to a year-long exercise intervention (225 min/week) or a control group while being asked to maintain a normal diet. Fasting blood samples were obtained and plasma concentrations of two oxidative damage markers (8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostaglandin F2α (8-Iso-PGF2α)) and two antioxidant enzymes (superoxide dismutase and catalase) were measured at baseline, 6 months and 12 months. Intention-to-treat (ITT) and per-protocol analyses were performed using linear mixed models adjusted for baseline biomarker concentrations. A further exercise adherence analysis, based on mean minutes of exercise per week, was also performed.
In the ITT and per-protocol analyses, the exercise intervention did not have any statistically significant effect on either oxidative damage biomarkers or antioxidant enzyme activity.
A year-long aerobic exercise intervention did not have a significant impact on oxidative stress in healthy, postmenopausal women.
NCT00522262.
氧化应激可能通过多种机制导致癌症病因，这些机制包括对DNA、蛋白质和脂质的损伤，进而导致基因突变和基因组不稳定。本研究的目的是确定有氧运动对绝经后女性氧化损伤标志物和抗氧化酶的影响。
艾伯塔省体育活动与乳腺癌预防试验（ALPHA）是一项双中心、双臂随机试验，共有320名年龄在50 - 74岁、不活跃、健康的绝经后女性参与。参与者被随机分配到为期一年的运动干预组（每周225分钟）或对照组，同时要求保持正常饮食。在基线、6个月和12个月时采集空腹血样，测量两种氧化损伤标志物（8 - 羟基 - 2'-脱氧鸟苷（8 - OHdG）和8 - 异前列腺素F2α（8 - Iso - PGF2α））以及两种抗氧化酶（超氧化物歧化酶和过氧化氢酶）的血浆浓度。使用针对基线生物标志物浓度进行调整的线性混合模型进行意向性分析（ITT）和符合方案分析。还基于每周平均运动分钟数进行了进一步的运动依从性分析。
在ITT和符合方案分析中，运动干预对氧化损伤生物标志物或抗氧化酶活性均无统计学上的显著影响。
为期一年的有氧运动干预对健康绝经后女性的氧化应激没有显著影响。
NCT00522262。
