Lau Siu Ha, Reddy Suganya, Cheesbrough John, Bolton Frederick J, Willshaw Geraldine, Cheasty Tom, Fox Andrew J, Upton Mathew
Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building 1, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom.
J Clin Microbiol. 2008 Mar;46(3):1076-80. doi: 10.1128/JCM.02065-07. Epub 2008 Jan 16.
A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.
共有88株尿路致病性大肠杆菌分离株，其中68株来自尿液，20株来自血液，采用多位点序列分型（MLST）进行特征分析。MLST已鉴定出大肠杆菌的一个重要遗传谱系，称为序列类型131（ST-131），这些分离株中有52株属于该谱系，其中51株对超广谱头孢菌素耐药。ST-131似乎是一种耐药的尿路致病性大肠杆菌菌株，可导致尿路感染和菌血症，并且在英格兰西北部不同地理区域的社区和医院患者中广泛传播。MLST的应用有助于确定可能构成致病性大肠杆菌菌株流行病学基础的群体生物学。MLST的便携性使得能够准确监测这种耐药的尿路致病性大肠杆菌菌株，并将加强对这一重要微生物群体的监测。
