在伊朗人群中，无证据表明去甲肾上腺素转运体-3081（A/T）多态性与注意力缺陷多动障碍之间存在关联。
No Evidence for Association Between Norepinephrine Transporter-3081 (A/T) Polymorphism and Attention Deficit Hyperactivity Disorder in Iranian Population.
作者信息
Eslami Amirabadi Mohammad Reza, Davari-Ashtiani Rozita, Khademi Mojgan, RajeziEsfahani Sepideh, Emamalizadeh Babak, Movafagh Abolfazl, Arabgol Fariba, Sadr Said, Darvish Hossein, Razjouyan Katayoon
机构信息
Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Department of Psychiatry, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
出版信息
Iran Red Crescent Med J. 2015 Jul 23;17(7):e22996. doi: 10.5812/ircmj.229961v2. eCollection 2015 Jul.
BACKGROUND
Attention Deficit Hyperactivity Disorder (ADHD) can lead to drastic problems for the patient and its worldwide prevalence is 5%-12%. It also has many comorbidities with other disorders, and the genetic contribution seems the most significant cause.
OBJECTIVES
The current study was conducted to investigate the association between norepinephrine transporter-3081 (A/T) polymorphisms and ADHD in Iranian population.
PATIENTS AND METHODS
Participants were chosen from children and adolescents diagnosed with ADHD referred to Imam Hoseyn Hospital. A child and adolescent psychiatrist confirmed the diagnosis using the Kiddie-Sads-Present and Lifetime Version (K-SADS-PL) semi-structural interview. The control group was from pupils of schools in Tehran (capital city of Iran) who had no history or presence of psychiatric and medical complications. Also, a child and adolescent psychiatrist confirmed their health using the K-SADS-PL semi-structural interview. Genetic examinations were DNA distraction, Polymerase Chain Reaction (PCR), and Restricted Fragment Length Polymorphism (RFLP), which were conducted according to standard protocols. The statistical analysis was performed using chi-square and Fisher's exact test in SPSS version 21.
RESULTS
The percentages of ADHD subtypes for combined, inattentive, and hyperactive/impulsive were 72.2%, 17.2%, and 11.9%, respectively. There was no significant association between norepinephrine transporter polymorphism and ADHD (P = 0.81). Moreover, no significant relationship was found between gender [male (P = 0.92) and female (P = 0.63)] and polymorphism. No significant association was found between subtypes of ADHD [combined (P = 0.46), inattentive (P = 0.41), hyperactive/impulsive (P = 0.32)] and polymorphism SCL6A2. This lack of association can also be seen in gender in every subtype.
CONCLUSIONS
The results of the study show no significant association between norepinephrine transporter polymorphism SCL6A2 and ADHD.
背景
注意力缺陷多动障碍（ADHD）会给患者带来严重问题，其全球患病率为5% - 12%。它还与其他疾病有许多共病情况，而遗传因素似乎是最主要的病因。
目的
本研究旨在调查伊朗人群中去甲肾上腺素转运体 - 3081（A/T）多态性与ADHD之间的关联。
患者与方法
参与者选自被转诊至伊玛目侯赛因医院诊断为ADHD的儿童和青少年。一名儿童及青少年精神科医生使用儿童版情感障碍和精神分裂症问卷（Kiddie - Sads - Present and Lifetime Version，K - SADS - PL）半结构式访谈来确诊。对照组来自德黑兰（伊朗首都）学校的学生，他们没有精神和医疗并发症的病史或症状。同样，一名儿童及青少年精神科医生使用K - SADS - PL半结构式访谈来确认他们的健康状况。基因检测采用DNA提取、聚合酶链反应（PCR）和限制性片段长度多态性分析（RFLP），均按照标准方案进行。使用SPSS 21版软件进行卡方检验和Fisher精确检验进行统计分析。
结果
混合型、注意力不集中型和多动/冲动型ADHD亚型的比例分别为72.2%、17.2%和11.9%。去甲肾上腺素转运体多态性与ADHD之间无显著关联（P = 0.81）。此外，性别[男性（P = 0.92）和女性（P = 0.63）]与多态性之间也未发现显著关系。ADHD各亚型[混合型（P = 0.46）、注意力不集中型（P = 0.41）、多动/冲动型（P = 0.32）]与多态性SCL6A2之间均未发现显著关联。在各亚型的性别方面也未发现这种关联。
结论
研究结果表明去甲肾上腺素转运体多态性SCL6A2与ADHD之间无显著关联。
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