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遗传风险与 ADHD 症状:在基于收养的研究中探索父母反社会行为的影响。

Genetic risks and ADHD symptomatology: exploring the effects of parental antisocial behaviors in an adoption-based study.

机构信息

College of Criminology and Criminal Justice, Florida State University, 634 W. Call Street, Tallahassee, FL 32306-1122, USA.

出版信息

Child Psychiatry Hum Dev. 2012 Apr;43(2):293-305. doi: 10.1007/s10578-011-0263-0.

DOI:10.1007/s10578-011-0263-0
PMID:22020991
Abstract

A great deal of research has examined the etiology of attention-deficit/hyperactivity disorder (ADHD) and ADHD symptomatologies. Genetic factors are consistently shown to explain a significant proportion of variance in measures of ADHD. The current study adds to this body of research by examining whether genetic liabilities for criminality and alcoholism have effects on the development of ADHD symptomatologies. Analyses based on a sample of adoptees drawn from the National Longitudinal Study of Adolescent Health (Add Health) revealed that ADHD symptomatologies were elevated among adoptees who had biological mothers and fathers who had been arrested or who were alcoholics. These results suggest that part of the covariation between ADHD and antisocial behaviors may be the result of genetic factors that have general effects across a range of maladaptive outcomes.

摘要

大量研究已经探讨了注意缺陷多动障碍(ADHD)和 ADHD 症状的病因。遗传因素一直被证明可以解释 ADHD 测量中很大一部分差异。本研究通过检查犯罪和酗酒的遗传倾向是否对 ADHD 症状的发展有影响,为这一研究领域做出了贡献。基于从全国青少年健康纵向研究(Add Health)中抽取的领养者样本进行的分析表明,那些亲生父母有被捕或酗酒史的领养者的 ADHD 症状更为明显。这些结果表明,ADHD 与反社会行为之间的部分共变可能是遗传因素的结果,这些遗传因素对一系列适应不良的结果具有普遍影响。

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Genetic risks and ADHD symptomatology: exploring the effects of parental antisocial behaviors in an adoption-based study.遗传风险与 ADHD 症状:在基于收养的研究中探索父母反社会行为的影响。
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本文引用的文献

1
Genetic influences on being processed through the criminal justice system: results from a sample of adoptees.遗传因素对被刑事司法系统处理的影响:来自领养者样本的结果。
Biol Psychiatry. 2011 Feb 1;69(3):282-7. doi: 10.1016/j.biopsych.2010.09.007. Epub 2010 Nov 10.
2
Increasing prevalence of parent-reported attention-deficit/hyperactivity disorder among children --- United States, 2003 and 2007.儿童注意缺陷多动障碍报告发病率增加——美国,2003 年和 2007 年。
MMWR Morb Mortal Wkly Rep. 2010 Nov 12;59(44):1439-43.
3
Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD).
将碎片拼合在一起:当前关于注意缺陷多动障碍(ADHD)遗传基础的研究。
Neuropsychiatr Dis Treat. 2010 Sep 7;6:551-60. doi: 10.2147/NDT.S11322.
4
Prevalence and treatment of mental disorders among US children in the 2001-2004 NHANES.2001-2004 年美国国家健康与营养调查中儿童精神障碍的流行状况和治疗情况。
Pediatrics. 2010 Jan;125(1):75-81. doi: 10.1542/peds.2008-2598. Epub 2009 Dec 14.
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Gene-environment interactions in attention-deficit/hyperactivity disorder.注意缺陷多动障碍的基因-环境相互作用。
Curr Psychiatry Rep. 2009 Oct;11(5):387-92. doi: 10.1007/s11920-009-0058-1.
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Candidate gene studies of ADHD: a meta-analytic review.注意力缺陷多动障碍的候选基因研究:一项荟萃分析综述
Hum Genet. 2009 Jul;126(1):51-90. doi: 10.1007/s00439-009-0694-x. Epub 2009 Jun 9.
7
Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.注意缺陷多动障碍儿童的候选基因与神经心理学表型:关联研究综述
J Psychiatry Neurosci. 2009 Mar;34(2):88-101.
8
Development of adolescence-limited, late-onset, and persistent offenders from age 8 to age 48.从8岁到48岁青少年受限型、晚发型和持续性犯罪者的发展情况。
Aggress Behav. 2009 Mar-Apr;35(2):150-63. doi: 10.1002/ab.20296.
9
A common genetic factor explains the covariation among ADHD ODD and CD symptoms in 9-10 year old boys and girls.一个常见的遗传因素解释了9至10岁男孩和女孩中多动症、对立违抗性障碍和品行障碍症状之间的共变关系。
J Abnorm Child Psychol. 2009 Feb;37(2):153-67. doi: 10.1007/s10802-008-9278-9.
10
Gene-environment interplay and the importance of self-control in predicting polydrug use and substance-related problems.基因-环境相互作用以及自我控制在预测多药滥用和物质相关问题中的重要性。
Addict Behav. 2009 Jan;34(1):112-6. doi: 10.1016/j.addbeh.2008.08.011. Epub 2008 Sep 5.