Esen Salman Kübra, Kıvanç Altunay İlknur, Salman Andaç
Turk J Med Sci. 2019 Apr 18;49(2):595-603. doi: 10.3906/sag-1810-110.
BACKGROUND/AIM: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders
This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Demographic features, phototherapy parameters, and adverse effects were evaluated in all patients, and the treatment response was assessed in patients who attended at least one follow-up visit.
A total of 173 patients (102 females; 71 males) with vitiligo, alopecia areata, lichen simplex chronicus, palmoplantar psoriasis, and psoriasis vulgaris were included in the study. Among 73 patients, with whom the treatment was finalized by physician, an excellent response was obtained in 10%, 52.9%, 53.8%, 28.6%, and 40% of patients with vitiligo, alopecia areata, lichen simplex chronicus, palmoplantar psoriasis, and psoriasis, respectively. The treatment was generally well tolerated and was discontinued in only two patients due to adverse effects.
This study demonstrates that targeted narrowband UVB therapy is a safe and effective treatment alternative, particularly for alopecia areata, lichen simplex chronicus, and palmoplantar and plaque-type psoriasis.
背景/目的：光疗是治疗多种皮肤病的一种安全有效的方法。近年来，靶向光疗因其相对于传统光疗的优势而变得愈发重要。本回顾性研究旨在评估靶向窄谱中波紫外线（UVB）光疗对皮肤病患者的安全性和疗效。
这项单中心研究纳入了173例接受靶向窄谱UVB光疗的患者。评估了所有患者的人口统计学特征、光疗参数及不良反应，并对至少参加了一次随访的患者的治疗反应进行了评估。
该研究共纳入了173例患有白癜风、斑秃、慢性单纯性苔藓、掌跖银屑病和寻常型银屑病的患者（102例女性；71例男性）。在73例由医生完成治疗的患者中，白癜风、斑秃、慢性单纯性苔藓、掌跖银屑病和银屑病患者的极佳反应率分别为10%、52.9%、53.8%、28.6%和40%。该治疗总体耐受性良好，仅2例患者因不良反应而中断治疗。
本研究表明，靶向窄谱UVB疗法是一种安全有效的治疗选择，尤其适用于斑秃、慢性单纯性苔藓以及掌跖和斑块型银屑病。
