Loprieno N, Boncristiani G, Loprieno G, Tesoro M
Dipartimento di Scienze dell'Ambiente e del Territorio, University of Pisa, Italy.
Environ Health Perspect. 1991 Dec;96:121-6. doi: 10.1289/ehp.9196121.
A database containing qualitative and quantitative results of experimental studies in the fields of genotoxicity and carcinogenicity has been developed. By analyzing results of the studies performed by the U.S. National Toxicology Program, or by a similar program developed in Japan, or reported in the scientific literature, as well performed by private organizations, information has been collected relating to 3389 chemicals, identified by their CAS number. The studies considered for the database include three genotoxicity/mutagenicity short-term test (STTs), namely, two in vitro (Salmonella, gene mutation assay, and mammalian cells/human lymphocytes chromosome aberration assay) and one in vivo, the rodent bone marrow micronucleus assay. To investigate the possible predictive value of these STT assays for carcinogenicity, the results of animal long-term bioassays have also been collected. We have re-evaluated all the genotoxicity studies and the majority of those cases studied in different laboratories with contrasting results has been resolved; a small proportion of questionable cases is, however, still present in the database. In total, 2898 (85.5%) of the chemicals have been tested in the Salmonella assay; 1399 (41.3%) have been tested in the in vitro chromosome aberration assay; 319 (9.4%) have been tested in the in vivo rodent bone marrow cell micronucleus assay; 716 (21.2%) of the chemicals have been tested in the in vivo animal long-term bioassay. For 1118 chemicals tested in the Salmonella assay, 30,650 quantitative studies have been included in the database, thus allowing a possible classification of mutagenic chemicals according to their mutagenic potency.(ABSTRACT TRUNCATED AT 250 WORDS)
现已建立了一个包含遗传毒性和致癌性领域实验研究定性和定量结果的数据库。通过分析美国国家毒理学计划开展的研究结果，或日本开展的类似计划的结果，或科学文献中报道的结果，以及私人组织开展的研究结果，收集了与3389种化学物质相关的信息，这些化学物质通过其化学物质登录号进行识别。该数据库考虑的研究包括三种遗传毒性/诱变性短期试验（STT），即两种体外试验（沙门氏菌基因突变试验和哺乳动物细胞/人类淋巴细胞染色体畸变试验）和一种体内试验，即啮齿动物骨髓微核试验。为了研究这些短期试验对致癌性的可能预测价值，还收集了动物长期生物测定的结果。我们重新评估了所有遗传毒性研究，不同实验室研究结果相互矛盾的大多数情况已得到解决；然而，数据库中仍存在一小部分有疑问的情况。总共有2898种（85.5%）化学物质进行了沙门氏菌试验；1399种（41.3%）进行了体外染色体畸变试验；319种（9.4%）进行了体内啮齿动物骨髓细胞微核试验；716种（21.2%）化学物质进行了体内动物长期生物测定。对于在沙门氏菌试验中测试的1118种化学物质，数据库中纳入了30650项定量研究，从而有可能根据诱变效力对诱变化学物质进行分类。（摘要截短为250字）
