Hayashi M, Kishi M, Sofuni T, Ishidate M
Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, Japan.
Food Chem Toxicol. 1988 Jun;26(6):487-500. doi: 10.1016/0278-6915(88)90001-4.
A total of 47 chemical substances including 32 synthetic food additives, seven additives from natural sources, three trihalogenated methanes, two fluoro-compounds for dental use, one insecticide, and two other compounds were subjected to the micronucleus test in mice. Five compounds, i.e. chlorine dioxide, maltol, potassium bromate, sodium chlorite and sodium dehydroacetate, were found to induce micronuclei after a single ip injection. Potassium bromate, sodium chlorite and sodium dehydroacetate were tested further by oral administration, and potassium bromate showed a clearly positive result. Almost all the compounds which were negative with the single treatment were additionally tested by four or five multiple treatments, but none showed any indication of micronucleus induction.
总共47种化学物质，包括32种合成食品添加剂、7种天然来源的添加剂、3种三卤甲烷、2种牙科用氟化合物、1种杀虫剂和2种其他化合物，在小鼠身上进行了微核试验。5种化合物，即二氧化氯、麦芽酚、溴酸钾、亚氯酸钠和脱氢醋酸钠，单次腹腔注射后被发现可诱导微核。对溴酸钾、亚氯酸钠和脱氢醋酸钠进一步进行口服给药测试，溴酸钾显示出明显的阳性结果。几乎所有单次处理呈阴性的化合物都额外进行了四五次重复处理测试，但没有一种显示出微核诱导的迹象。
