耻垢分枝杆菌抗生素抗性突变体中核糖体的改变
Altered ribosomes in antibiotic-resistant mutants of Mycobacterium smegmatis.
作者信息
Yamada T, Masuda K, Mizuguchi Y, Suga K
出版信息
Antimicrob Agents Chemother. 1976 May;9(5):817-23. doi: 10.1128/AAC.9.5.817.
Abstract
Two alleles for viomycin-capreomycin resistance (vic) in Mycobacterium smegmatis affect ribosome structures. One (vicA) affects a component of 50S subunits and the other (vicB) affects a component of 30S subunits. The locus for neomycin-kanamycin resistance (nek), which is linked to vicA and vicB, affects a component of 30S subunits. Although the erythromycin resistance locus (ery) is linked to vic and nek, no ribosomal alterations could be detected. Mutations at the streptomycin locus (str) not linked to vic and nek caused alterations of 30S subunits.
摘要
耻垢分枝杆菌中两种对紫霉素-卷曲霉素耐药的等位基因（vic）影响核糖体结构。一种（vicA）影响50S亚基的一个组分，另一种（vicB）影响30S亚基的一个组分。与vicA和vicB连锁的新霉素-卡那霉素耐药位点（nek）影响30S亚基的一个组分。尽管红霉素耐药位点（ery）与vic和nek连锁，但未检测到核糖体改变。与vic和nek不连锁的链霉素位点（str）的突变导致30S亚基的改变。
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