Mattar Fabiana Luisa, Sobreira Claudia
Department of Neurology, Psychiatry and Medical Psychology, Faculty of Medicine of Ribeirao Preto, São Paulo University, Brazil.
Neuromuscul Disord. 2008 Mar;18(3):193-8. doi: 10.1016/j.nmd.2007.11.004. Epub 2008 Jan 22.
The purpose of this study was to determine the age of hand involvement in Duchenne muscular dystrophy (DMD), since various types of hand dynamometry have been applied to evaluate patients in clinical trials. We studied 40 patients with DMD from our university hospital clinic and 80 healthy, age-matched controls. Hand strength was evaluated by handgrip and pinch dynamometries, and by manual testing. Physical disability was measured with a functional scale. Hand weakness was present since early stages in patients with DMD. However, hand strength tended to increase with age in the first decade, although never reaching the control values. Decrease of strength occurred later. Handgrip and pinch dynamometry values were significantly correlated with global hand strength, which were inversely correlated with functional capacity only in the group older than 10 years. Hand dynamometry should be applied with caution as an outcome measure in therapeutical trials in young patients with DMD.
本研究的目的是确定杜氏肌营养不良症（DMD）患者手部受累的年龄，因为在临床试验中已应用各种类型的握力测量法来评估患者。我们研究了来自我校医院门诊的40例DMD患者以及80名年龄匹配的健康对照者。通过握力和捏力测量法以及手动测试来评估手部力量。用功能量表测量身体残疾情况。DMD患者在疾病早期就存在手部无力。然而，在第一个十年中，手部力量往往随年龄增长而增加，尽管从未达到对照值。力量下降发生在较晚阶段。握力和捏力测量值与整体手部力量显著相关，而仅在10岁以上的组中，这些值与功能能力呈负相关。在年轻的DMD患者的治疗试验中，作为一项结果指标应用握力测量法时应谨慎。
