Inamadar Arun C, Palit Aparna, Sampagavi V V, Raghunath S, Deshmukh N S
Department of Dermatology, Venereology and Leprosy, BLDEA's SBMP Medical College, Hospital and Research Center, Bijapur, Karnataka, India.
Int J Dermatol. 2008 Feb;47(2):154-9. doi: 10.1111/j.1365-4632.2008.03478.x.
BACKGROUND; Chikungunya fever is an Aedes mosquito-borne Arbo viral illness with significant morbidity.
In a recent outbreak of the disease in south India, the dermatologic manifestations of 145 patients attending a tertiary care hospital were recorded.
All age groups were affected, including newborns. Some of the cutaneous features were observed during the acute stage of the illness, and others during convalescence or thereafter. Pigmentary changes were found to be the most common cutaneous finding (42%), followed by maculopapular eruption (33%) and intertriginous aphthous-like ulcers (21.37%). Lesions with significant morbidity were generalized vesiculobullous eruptions (2.75%), found only in infants, lymphedema, and intertriginous aphthous-like ulcers. Exacerbation of existing dermatoses, such as psoriasis, and unmasking of undiagnosed Hansen's disease were observed. A perivascular lymphocytic infiltrate was a consistent histopathologic finding in all types of skin lesions. All patients responded well to symptomatic, conservative treatment.
The cutaneous findings hitherto not reported may be the result of the African genotype of the virus detected during this outbreak in India.
背景：基孔肯雅热是一种由伊蚊传播的虫媒病毒性疾病，发病率较高。
在印度南部最近一次该疾病的暴发中，记录了一家三级护理医院收治的145例患者的皮肤表现。
所有年龄组均受影响，包括新生儿。一些皮肤特征在疾病急性期出现，另一些在恢复期或之后出现。色素沉着改变是最常见的皮肤表现（42%），其次是斑丘疹（33%）和间擦部位的口疮样溃疡（21.37%）。具有较高发病率的皮损为泛发性水疱大疱性皮疹（2.75%），仅见于婴儿、淋巴水肿和间擦部位的口疮样溃疡。观察到现有皮肤病如银屑病加重，以及未诊断出的麻风病被发现。血管周围淋巴细胞浸润是所有类型皮肤病变一致的组织病理学表现。所有患者对对症、保守治疗反应良好。
迄今未报道的皮肤表现可能是此次印度暴发期间检测到的病毒非洲基因型的结果。
