Lalitha Prajna, Rathinam Sivakumar, Banushree Krishnadas, Maheshkumar Shanmugam, Vijayakumar Rajendran, Sathe Padmakar
Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, India.
Am J Ophthalmol. 2007 Oct;144(4):552-6. doi: 10.1016/j.ajo.2007.06.002. Epub 2007 Aug 9.
To study the range of ocular symptoms in a cohort of patients with chikungunya infection.
Retrospective, observational case series.
Patients attending a tertiary eye care hospital in South India were included in the study. We included adult patients with serologically confirmed chikungunya virus infection who received clinical care at the Aravind Eye Hospital, Madurai, South India. They were assessed for demographic characteristics, ocular symptoms, laboratory parameters, and chikungunya virus infection severity. Patients underwent a complete ophthalmologic examination that included visual acuity, slit-lamp examination, and indirect funduscopic examination. Visual outcome at the end of three months was the main outcome measure.
The charts of 37 patients were analyzed based on the clinical picture and the serologic results. Forty patients were included as controls and tested negative. There were 21 males and 16 females with a mean age of 44.17 years. The main ocular symptoms included granulomatous and nongranulomatous anterior uveitis, optic neuritis retrobulbar neuritis, and dendritic lesions. Of the 26 patients who were followed up for three months, the visual acuity improved in 11 patients (42.3%), remained the same in 12 patients (46.15%), and worsened in three patients (11.5%).
The main ocular manifestation associated with the recent epidemic outbreak of chikungunya virus infection in South India included granulomatous and nongranulomatous anterior uveitis, optic neuritis, retrobulbar neuritis, and dendritic lesions. The visual prognosis generally was good, with most patients recovering good vision. Further studies are needed to understand the pathogenesis of this disease.
研究一群基孔肯雅热感染患者的眼部症状范围。
回顾性观察病例系列。
纳入在印度南部一家三级眼科护理医院就诊的患者。我们纳入了在印度南部马杜赖的阿拉文德眼科医院接受临床护理、血清学确诊为基孔肯雅病毒感染的成年患者。对他们进行人口统计学特征、眼部症状、实验室参数和基孔肯雅病毒感染严重程度的评估。患者接受了包括视力、裂隙灯检查和间接检眼镜检查在内的全面眼科检查。三个月末的视力结果是主要观察指标。
根据临床表现和血清学结果分析了37例患者的病历。纳入40例患者作为对照，检测结果为阴性。有21名男性和16名女性，平均年龄44.17岁。主要眼部症状包括肉芽肿性和非肉芽肿性前葡萄膜炎、视神经炎、球后视神经炎和树突状病变。在随访三个月的26例患者中，11例患者（42.3%）视力改善，12例患者（46.15%）视力不变，3例患者（11.5%）视力恶化.
与印度南部近期基孔肯雅病毒感染疫情相关的主要眼部表现包括肉芽肿性和非肉芽肿性前葡萄膜炎、视神经炎、球后视神经炎和树突状病变。视力预后总体良好，大多数患者恢复了良好的视力。需要进一步研究以了解该疾病的发病机制。
